$VRTX

Top Institutions

1

Capital World Investors

25,368,124 shares

1.55%

% of Portfolio

2

AllianceBernstein (AB)

3,910,786 shares

0.57%

% of Portfolio

3

Janus Henderson Group

2,131,527 shares

0.47%

% of Portfolio

4

Renaissance Technologies

421,688 shares

0.29%

% of Portfolio

5

Wellington Management

3,212,589 shares

0.27%

% of Portfolio

6

Voya Investment Mgmt

527,047 shares

0.24%

% of Portfolio

7

Legal & General

1,955,764 shares

0.20%

% of Portfolio

8

Jennison Associates

2,740,059 shares

0.84%

% of Portfolio

9

Capital International Investors

5,126,077 shares

0.54%

% of Portfolio

10

Robeco Institutional Asset Management

401,644 shares

0.26%

% of Portfolio

11

Larry Fink - BlackRock

23,969,517 shares

0.19%

% of Portfolio

12

Neuberger Berman

551,522 shares

0.19%

% of Portfolio

13

State Street Corp

11,730,139 shares

0.18%

% of Portfolio

14

Invesco

2,561,057 shares

0.18%

% of Portfolio

15

Mitsubishi Ufj Asset Management Co., Ltd.

597,497 shares

0.18%

% of Portfolio

16

Ensign Peak Advisors

215,165 shares

0.18%

% of Portfolio

17

Geode Capital Management

6,139,621 shares

0.17%

% of Portfolio

18

Adage Capital Partners

251,990 shares

0.17%

% of Portfolio

19

Lazard Asset Management

213,131 shares

0.16%

% of Portfolio

20

Northern Trust Corp

2,564,264 shares

0.15%

% of Portfolio

21

CalPERS

503,374 shares

0.14%

% of Portfolio

22

Two Sigma Investments

378,146 shares

0.14%

% of Portfolio

23

Charles Schwab

1,920,871 shares

0.13%

% of Portfolio

24

Nuveen

1,084,495 shares

0.13%

% of Portfolio

25

David Solomon - Goldman Sachs

2,417,875 shares

0.12%

% of Portfolio

26

Morgan Stanley

3,188,881 shares

0.09%

% of Portfolio

27

T. Rowe Price

1,760,122 shares

0.09%

% of Portfolio

28

BNP Paribas

415,625 shares

0.09%

% of Portfolio

29

David E. Shaw - D.E. Shaw & Co.

248,960 shares

0.07%

% of Portfolio

30

Franklin Resources

551,132 shares

0.06%

% of Portfolio

31

Canada Pension Plan Investment Board

190,051 shares

0.05%

% of Portfolio

32

Jan van Eck - VanEck

146,116 shares

0.05%

% of Portfolio

33

UBS Group

630,618 shares

0.04%

% of Portfolio

34

Cliff Asness - AQR Capital Management

171,031 shares

0.03%

% of Portfolio

35

SG Americas Securities

56,982 shares

0.03%

% of Portfolio

36

Ken Griffin - Citadel Advisors

339,298 shares

0.02%

% of Portfolio

37

Dmitry Balyasny - Balyasny Asset Management

40,137 shares

0.02%

% of Portfolio

38

Israel Englander - Millennium Management

30,823 shares

0.01%

% of Portfolio

39

Jane Street Group

122,946 shares

0.01%

% of Portfolio

40

Baillie Gifford

199,421 shares

0.09%

% of Portfolio

41

PNC Financial Services

71,942 shares

0.02%

% of Portfolio

42

Fidelity International (FIL)

21,623 shares

0.01%

% of Portfolio

43

Mike Hankin - Brown Advisory INC

7,653 shares

0.01%

% of Portfolio

44

Ken Fisher - Fisher Asset Management

31,158 shares

NaN%

% of Portfolio

45

Manning & Napier

220,589 shares

1.39%

% of Portfolio

46

Lord, Abbett & Co. LLC

166,509 shares

0.24%

% of Portfolio

47

Segall Bryant & Hamill, LLC

29,994 shares

0.24%

% of Portfolio

48

New York State Teachers Retirement System